MIKHAIL BLAGOSKLONNY ; THE SCIENTIST BEHIND THE ROLE OF TARGET OF RAPAMYCIN (TOR) IN AGING

The world has seen the rise of many innovative, creative and curious scientists who research various aspects of science and make huge contributions. According to Impact Journals, Mikhail Blagosklonny is one of them. His research interests include molecular and cellular biology, signal transduction, cell cycle, oncogenes and tumor suppressors and anti-cancer therapeutics.

He aims at understanding aging and cancer, two of the largest dilemmas in the world today. One of his main achievements is the development of a hypothesis about the possible role of Target Of Rapamycin (TOR) in the aging of humans and other organisms.

According to Mikhail Blagosklonny, TOR, being a nutrient sensing path, determines how an organism’s body coordinates growth and aging. He argues that aging results from cellular senescence. This is the continuous development of the cells even after the organism has reached its maximum development stage.

It leads to overworking of the cells thus blocking the feedback pathways and further impairing their functioning. This leads to cell deterioration, aging and age-related diseases which may cause organ damage and even death due to lack of homeostasis.

Since TOR is triggered by nutrients, insulin and growth factors, it causes cell-hyper-function. As such, TOR presence is directly related to every age-related disease. From his findings, he proposed that a cancer drug called rapamycin may be a possible treatment for life extension.

Mikhail Blagosklonny currently works at the Roswell Park Cancer Institute in New York as a professor of Oncology. He began this job on April 2009 when he was appointed as an associate professor. At the facility, he facilitates the development of innovative cancer treatments, prevention methods and anti-cancer stratagem.

When he is not teaching at the institute, he is editing scholarly research articles. He is the Founding editor and Editor-in-chief of Cell Cycle and co-editor and Co-founder of Aging, Oncotarget and Oncoscience.

A master’s degree in internal medicine and PHD in experimental medicine and cardiology, both from the First Pavlov State Medical University of St. Peterburg, laid a great foundation for Mikhail’s career.

He began his teaching career at The New York Medical College in Valhalla in 2002 when he was appointed associate professor of medicine. He worked there until 2009.

Anthony Petrello: Oil Industry Leader And Texas Children’s Hospital Philanthropist

Anthony Petrello heads up one of the nation’s most prestigious oil drilling companies, Nabors Industries. Nabors is based in Houston and has built one of the largest rig fleets both in land and offshore operations, and has a lot of investors that own shares of its stock. As Chairman of Nabors, Petrello helps plan strategic initiatives for the company in order to maximize drilling production and attract more investments in the company. He’s led investments into both drilling operational technology, and the development of proprietary software and automated technology. Petrello has been with Nabors since 1991 and is also on the boards of several other organizations including Stewart & Stevenson and Hilcorp.

Petrello is originally from Newark, NJ and as a young man thought he might go into a career related to mathematics. He excelled at the subject in high school and was able to get a scholarship to Yale University where he studied under world famous math Professor Serge Lange. Petrello graduated with high honors in both his bachelor’s and master’s degree, but he decided not to pursue a career in the field and opted to go into law instead. After getting a J.D. from Harvard, he joined Baker & McKenzie law firm in New York where he practiced corporate law for about 13 years. He became a partner at the firm in 1986. But he changed careers yet again in 1991 after Nabors Industries offered him a position as Chief Operating Officer. 20 years later Petrello became Chairman and CEO of Nabors.

Anthony Petrello is also on the Board of Trustees at the Texas Children’s Hospital in Houston helping to raise awareness and fundraising for neurological disorders. He joined this endeavor because he and his wife Cynthia Petrello have a daughter of their own named Carena who was diagnosed with Cerebral Palsy when she was born. He was told that there were no treatments available that could help Carena’s condition, so he decided to look into neurological research and help fund programs that might lead to cures. He met Dan and Jan Duncan who had also taken a keen interest in neurological diseases and research for cures, and with a generous gift to TCH’s research facility it was renamed in their honor. Petrello also made a donation of $7 million to research and he hopes more people understand the importance of helping these young children.

Traveling Vineyard Brings Delicious Wine Right to Our Living Rooms

Times have surely changed drastically. Women have different interests from those of the past. Tupperware and makeup are no longer the cool product party every woman is scrambling to host. Ask almost any woman what she wants, what she loves, and the answer is probably going to be “wine”.

Now there’s a way women can spread the happiness of wine far and wide. The Traveling Vineyard is a great way to earn money and have fun selling a product you believe in while creating a customer base that will keep coming back for more. The Traveling Vineyard can help make those ends meet plus some.

The Traveling Vineyard’s business model is infallible. People love wine. If they buy wine they’re sure to drink it, and that means they’ll be wanting more. And why wouldn’t they? The Traveling Vineyard offers 21 varieties of wine. Whether you love white or red or sweet and fizzy there’s bound to be a wine for everybody at a very reasonable price. Their wines are priced between $14 and $25. A delicious, consumable product at a reasonable price also means your customers will be calling you soon after to restock. That’s good news for everyone!

Related: http://www.blogwinecellar.com/2010/05/traveling-vineyard-going-out-of.html

Reviews from current Traveling Vineyard members reveals that it’s not just a job or just a company. They feel that Traveling Vineyard is a family. There’s always a huge network you can turn to if you have a question you need to be answered or a problem you need to be solved. If you’re considering a fun, enjoyable work from home opportunity you can’t go wrong with Traveling Vineyard.

Click here to learn more about The Traveling Vineyard.

 

Securus Technologies – GTL Inaccuracies 43

One of the biggest mistakes that companies make in the business world is making bad decision concerning public communication. There are so many ways to communicate with the public today that companies sometimes allow the wrong information to get out into the public. Usually many companies will use a press release to send out information for public consumption. The press release is a time tested method of providing information to the public.

 

However, if not handled properly, a press release can become more of a problem than a communication method. Recently GTL sent out a press release that became the topic of public conversation. The press release did not place the company in the best light. The press release contained GTL’s version of a dispute between Securus Technologies and GTL. The dispute concerned matters related to technology patent right issues between the two companies.

 

In the press release, GTL made many claims against Securus Technologies related to the technology patent rights dispute. Once Securus Technologies found out about the press release, Securus Technologies sent out its own press release in response. In its press release, Securus Technologies offered its thoughts on the claims made by GTL. Securus Technologies made it a point to state that the claims made by GTL were not based on accurate information and contained information that was not exactly correct.

 

I believe that Securus Technologies was able to defend itself successfully in the public eye against the claims made by GTL. Securus Technologies was able to point out what it felt were the issues with the press release sent out by GTL.

 

Securus Technologies  is a technology company that has an outstanding reputation in the markets that it serves.

 

 

Popular Wiki Pages and Edits

Wikipedia pages allow for the spread of current and up-to-date information. Wiki pages can be subject to editing by anyone, which makes them targets for misinformation. Wiki edits can spread fake news stories, spreading false rumors and hurting the reputation of people. Those who wish to protect their reputation or promote their brand may choose to hire professional wiki writers and editors to create content and monitor it. 2016 was an interesting year for wiki edits.

Certain topics draw in more edits than others. Controversial or popular news stories cause people to want to edit their pages more. Brexit, Panama Papers, and the Orlando nightclub shooting are among some of the most edited pages. Other times it is not always as apparent as to why these pages are so popular to edit. Ru Paul’s Drag Race or fictional character, Beverly Gray are two pages that racked up edits. Editors claimed their fascination with Vincent Van Gogh was to clear up incorrect information.

The top edited article for 2016 was the deaths page. 2016 was the year of many celebrity deaths, which drew the interest of the public. David Bowie, John Glenn, Prince, and Janet Reno are among some of the famous people who passed in 2016. The deaths of celebrities are always a popular subject. This page had over 18,000 edits.

The second entry was Donald Trump’s entry, which is no surprise considering the controversy of the election. His page may garner even more edits, because the president-elect tends to draw attention.

Fake news has become even more popular on social media, so these fake stories are starting to pop up on the pages of Wikipedia. The ability for anyone to edit a wiki page and the popularity of these fake pages have caused the need for wiki editors. Many people and companies who wish to maintain their online reputation. Getyourwiki.com is a professional writing and editing service which offers content creation and monitoring of pages.

Choosing an Event Planner

Do you need to hire an event planner? It does not have to be difficult. Just follow these steps.

Know the objective of your event. Answer the questions who, what, when, where, how, and why before you consult a planner.

Know why you are hiring a planner. What services do you need a planner to provide? Will the planner choose the venue, send invitations, arrange entertainment or be present at the event?

How much will your event cost? Your planner can help you determine a budget.

Find a qualified planner by checking with professional affiliations or by asking the local chamber of commerce or hotel convention departments. Professional associations and organizations that use planners will know whom they trust.

Before choosing, interview a few. At first, be brief with your details. Focus on their expertise. Ask about experience and contingency plans. Listen to what they say. Then, provide details. Planners will ask questions. They need to know about your event.

It may be difficult, especially if your planner is from out-of-town, but it is important to meet your planner in person. Try to build rapport.

Check your planner’s references. Call past clients and read reviews.

After choosing your planner, listen to his ideas.

Ask for the planner’s total budget. Know all costs and fees up front.

Negotiate terms and review the fine print. Never sign a contract until you have had it examined by an attorney.

Confirm details. Check with suppliers and venues. Confirm that deposits are paid. Follow-through can prevent bad experiences.

Be prepared to fire or to rehire a planner. Patience is good, and misunderstandings happen, but be sure that you are receiving the services for which you pay.

If the planning process does not go well, find a new planner. If everything does go well, consider hiring the same planner for future events.

Twenty Three Layers is a full-service event planning firm based in NYC.

Whether a corporate function or personal celebration, their creativity, energy, attention to detail and demand for perfection will surpass your expectations.

Regardless of the function, Twenty Three Layers will leverage knowledge and creative inspiration to deliver extraordinary results.

There are many event planning companies in NYC. But there is only one Twenty Three Layers.

Cotemar is Setting High Standards in Mexican Offshore Oil Extraction Sector

Cotemar is a prominent Mexican company that has served the oil industry for more than 36 years. It offers a wide spectrum of services to PEMEX, ranging from developing and upgrading offshore oil fields, using advanced vessels and machinery. Some of the major strategic business divisions of Cotemar include food and lodging, air transportation, maintenance and engineering, maintenance construction, and marine operation. The firm is a giant in the offshore oil industry, spearheading the production of hydrocarbons by leveraging the effective processes executed by experienced individuals.

Cotemar’s subsidiaries

Cotemar has three subsidiaries that help in delivering state-of-the-art solutions and equipment to the oil sector on saladecomunicacion.cotemar.com.mx. They are structured to address the specific problems that the clients face. They include Cocinas del Mar, Apoyo Logistico Marino, and SIPSA.

Cocinas del Mar

Cotemar offers its one of a kind accommodation services through this subsection. Accommodation and catering services are rendered on the numerous platforms and vessels operated by Cotemar. The platforms consist of cabins that can cater for the needs of 2 or 4 people. Additionally, the firm avails recreational areas, including cinemas, entertainment rooms, basketball courts, and gyms. Employees are responsible for providing food, laundry, cleaning of beddings, bedrooms, and washing of clothes.

The platforms and vessels operated by Cotemar have the capacity to offer first-class food and accommodation services to over 4,000 persons concurrently offshore. Safety is a valuable aspect that Cotemar has mastered to observe since its inception. The firm handles the procedure of receiving foodstuffs and other supplies with extra caution, ensuring highest standards of cleanliness and quality are maintained.

Apoyo Logistico Marino

Cotemar operates a logistic subsidiary known as Apoyo Logistico Marino. The firm has acquired and continues to acquire highly specialized vessels at http://cotemar.com.mx/compania/cotemar-quienes-somos/. It owns barges and tugboats, which transport huge structures needed for the production of hydrocarbons. It also has boats for transportation of abrasive materials in barite, sand, sludge, and in bulk. Combat boats are always on standby to respond to emergencies such as oil spills and fire. The firm has specialized vessel for transporting liquids and oils obtained from the platforms.

SIPSA

SIPSA is a giant when it comes to delivering groundbreaking services on Indeed.com.mx including reconstruction and engineering of offshore processing plants. It has a highly equipped and experienced team of workers who can efficiently carry out high-performance tasks both offshore and onshore.

Solvy’s Love Of Helping Students With Math

Math is a topic that is not for everyone. That said, there is no topic that everyone is going to do well at. However, math seems to be the one topic that a lot of people have trouble with. While people can do well with addition and subtraction, it can get a little difficult for people to deal with the more complex equations of Algebra and Calculus.

According to All Business, Alexei Beltyukov has helped with the development of an app that is going to make sure that people understand what they are studying. Alexei has helped with the development of Solvy.

In class, it is not enough for people to know the answer to the math problems, it is important for people to demonstrate how they came to the solution to the problem. Solvy is able to help people come up with the solutions and also demonstrates the steps they have taken in order to find the solutions.

Fortunately, Solvy is an app that is not only good for helping students learn math, but also allowing their students to learn in ways that are simple. Also, teachers will gain a lot of benefits from this in that they can customize the types of homework assignments that students will get.

Alexei Beltyukov has had a diverse career. For one thing, he has started working in medicine. He has helped out in the healthcare field for a little bit.

One thing that he has learned about is marketing. Marketing is one of the most important aspects of business. One thing that Solvy needed was marketing in order to bring it to the level of success it needs.

Securus Video Visitation App Will Change Lives This Christmas

Christmas is celebrated by people in different parts of the globe. The holiday is considered as a special time where families can bond and celebrate together. However, when a loved one is in prison, the holiday can be lonely. Securus Technologies is a communication and technology provider, and it is planning to make the season better for the individuals who are incarcerated.

 

The new Securus video visitation application will transform the lives of many people, especially during the festive season. An advert from the company shows how a father and son speak to each other on Christmas day. Using the new application, the father watches happily as the child opens his Christmas gifts. The kid is very excited, and he doesn’t not care that the father is not close to him at the moment.

 

Every child wants to have a gift for Christmas that is given by the parents. When the parent is away, the parent can be frustrated, and the festive season might not be the best time for the child. It is amazing to see the child and father enjoy the seasons, regardless of the fact that the father is far away from home.

 

This Christmas, the technology company will allow the inmates and their families to speak and interact for a longer time. The application is already being used in the prisons, and it has changed the lives of many. The company understands the importance of the holiday, and they also know that children need their parents in this holiday. This was the reason behind developing the unique communication tool.

 

Securus Technologies offers its customers several other services too. The company recently invented the video messaging service. It is evident that individuals are busy most of the time looking for a living. They do not have a chance to respond to important phone calls when an inmate makes a call. It is now possible for families and friends to get messages from their loved ones who are in jail. The service is also cheaper compared to the calls, and this means that the inmates can save some money.

 

Securus Technologies is headquartered in Dallas, and it has been very helpful to the inmates and their families. The company serves more than three thousand facilities in northern America.

JustFab, the Fabulous Journey

Starting out as the Chief Executive Officer and President of FitnessHeaven.Com. Mr. Ressler then moved on to Intermix where he was on the forefront in spearheading the core ventures that embraced shareholder value. And here, he met his to be long-term partner and friend and the co-founder of Intelligent Beauty- Adam Goldenberg (2010).

Don Ressler co-founded brand Ideas. He has raised over $100 million in capital for internet companies. At Intermix, he advocated for core ventures that enhanced the value of the shareholder and cofounded Alena media together with the skin care brand Hydroderm. In 2005, News Corporation acquired MySpace.com for over $650 million. Adam Goldenberg and Don Ressler later conceptualized and formed Intelligent Beauty.

TechStyle, then operating under the name JustFab, has received funding from US Venture Capital firm matrix partners in 2011($ 33 million). An additional 476 million came from Rho Ventures, Technology Crossover Ventures, and intelligent Beauty leading to the expansion of JustFab business to Canada, Germany, and the United Kingdom.

Read more: Happy in El Segundo: TechStyle COO Anton Von Rueden on the Perks of Life in the South Ba

TechStyle in January 2013 went into the acquisition of children’s fashion subscription company Fabkids.It continued with its operations and expanded internationally into Spain and France-acquiring FabShoes in May 2013 on Wikipedia.org. Shoe Dazzle was then acquired in August of the same year.

Acceleration of already fast-growth in international business and entering into new products was due to the company closing at $40 million as announced by the co-CEOs. An additional round of funding at $85 million was closed by the company in August 2014 which was led by Passport Special Opportunity Fund and the Participation from some investors such as matrix and the Shining capital.

JustFab set out as a business to come to the rescue of consumers by delivering trendy fashions at an incredible value. Along the way, the company expanded and grew in its operations, rebranding, merging with other companies just to mention a few transformations. JustFab and Fabletics (cofounded by Adan Ressler and Kate Hudson) are now inclusive brands under TechStyle and therefore this according to Ressler, it is a step towards the right direction. It gives the business, even more, muscle to carry out its functions and satisfy customers since then there a variety of products under its name.

TechStyle is set out in a business environment that provides for a good working environment and space for conducting business, and with a good market for their products.

Learn more about Don Ressler: https://www.youtube.com/user/Fabletics